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Image Search Results
Journal: Journal of Translational Medicine
Article Title: GeneBits: ultra-sensitive tumour-informed ctDNA monitoring of treatment response and relapse in cancer patients
doi: 10.1186/s12967-025-06993-3
Figure Lengend Snippet: Coverage and error metrics after UMI-assisted consensus calling. Deduplicated read depths and error rates for different commercial cell-free DNA reference standards (Twist Std v2, Horizon Std, OncoSpan Std), tested with the IDT and Twist library preparation and hybridization capture workflows. (A, B) Error rates when using only consensus reads formed by 1x, 2x, 3x, or ≥ 4x UMI families (PCR duplicates) using the IDT (A) or Twist (B) workflows. (C, D) Depth of coverage when using only consensus reads formed by ≥ 1x, ≥ 2x, ≥ 3x, or ≥ 4x UMI-families (PCR duplicates) using the IDT (C) or Twist (D) workflows. (E) Comparing error rates between three workflows using only duplex-consensus reads formed by ≥ 4x UMI-families. (F) Comparing the limit of detection (LOD) between three workflows using only duplex-consensus reads formed by ≥ 4x UMI-families. (Lower is better for error rates and LOD, higher is better for depth of coverage)
Article Snippet: The
Techniques: Hybridization